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Removal of X-chromosome DNA methylation data makes females and males cluster together. Females are indicated with red color and (F), and males are indicated with blue color and (M).We then tested if the average degree of DNA methylation of all analyzed sites differed between males and females.
We can’t imagine the stress or desire for normalcy that evacuees are feeling right now.
We next evaluated if there are epigenetic differences between sexes in human pancreatic islets.
The genome-wide DNA methylation pattern was analyzed with the Infinium Human Methylation450 Bead Chip array.
While the chromosome-wide DNA methylation level on the X-chromosome is higher in female versus male islets, the autosomes do not display a global methylation difference between sexes.
Methylation of 8,140 individual X-chromosome sites and 470 autosomal sites shows sex-specific differences in human islets.